[HTML][HTML] Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression
B Zhou, J Mu, Y Gong, C Lu, Y Zhao, T He, Z Qin - Redox biology, 2017 - Elsevier
Uncovering new therapeutic targets for renal fibrosis holds promise for the treatment of
chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have
been shown to effectively ameliorate pathological fibrotic responses. However, the
pharmacological effects and underlying mechanisms of these inhibitors in renal fibrosis
remain elusive. In this study, we determined that the inhibition of Brd4, a BET family member,
with a selective potent chemical inhibitor, JQ1, could prevent the development of renal …
chronic kidney diseases. Bromodomain and extra-terminal (BET) protein inhibitors have
been shown to effectively ameliorate pathological fibrotic responses. However, the
pharmacological effects and underlying mechanisms of these inhibitors in renal fibrosis
remain elusive. In this study, we determined that the inhibition of Brd4, a BET family member,
with a selective potent chemical inhibitor, JQ1, could prevent the development of renal …
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